AWS HealthOmics caches cancelled run outputs for Nextflow, WDL, CWL workflows

AI Impact Summary

AWS HealthOmics now caches completed task outputs of cancelled runs, enabling reuse of outputs and avoiding recomputation. When caching is enabled and a run is cancelled, outputs are automatically stored in the customer’s Amazon S3 bucket, allowing restarts from the cancellation point. The feature applies to Nextflow, WDL, and CWL runs in all listed regions, helping researchers accelerate iterative development and debugging. While this can significantly reduce compute time and cost for long-running workflows, it shifts some expense to S3 storage and requires appropriate data lifecycle controls.